What to Know About Refrigerating Supplements

Which supplements should you store in the fridge, and which are OK in a cupboard or closet?

Where to store supplements is one of the most common questions we receive on social media and in our Ask the Experts inbox. It can be confusing to know what to do with different products and formulas; is the fridge the right spot for all probiotics? Do softgels need to be kept cold so they don’t stick together? Do powders need to be refrigerated or are they OK in a cupboard or on the counter? Here’s what you need to know about refrigerating supplements.

General rules for storing supplements

When in doubt, check the directions! Storage recommendations should be included on the product label. Unless the directions say otherwise, keep your go-to supplements in a climate-controlled environment: not too hot, not too cold, not in direct sunlight, and not too humid. This is the best way to keep them at their best and preserve the formula.


Many probiotic brands do require refrigeration, though the best way to tell if your probiotic in particular should be stored in the fridge is to check the directions. Some probiotics are shelf-stable, meaning they can be kept at room temperature, while others require refrigeration to maintain potency. If your probiotic requires refrigeration, get it in the cold stat! They can lose potency quickly, even in as little as five to seven days.

Liquids and syrups

Storage for liquid supplements depends on the formula you’re using. Liquid multivitamins are best kept in the refrigerator to maintain potency and flavor, while syrups (like Sambucus Original Syrup or Umcka cough syrups, for example) are OK stored in a cupboard or closet. If it’s been awhile and you’re not sure whether or not that liquid supplement is expired, check out our explainer for more info. Certain liquid formulas, like our Chlorofresh® Liquid Chlorophyll, do require refrigeration – and you’ll love the icy mint flavor all the more when it’s chilled!


In general, probiotic powders should be kept in the refrigerator for maximum potency and efficacy. Other powders, including drink mixes and protein powders, don’t require refrigeration and can be kept in a cool, dry spot unless the directions say otherwise.

Softgels and gummies

Softgels and gummies don’t need to be refrigerated, but you should pay attention to the climate you’re storing them in. They can clump together if they get too hot or humid, so it’s a good idea to keep them in a cool, dark, and dry environment if you can – the bathroom is not the best place for these formulas!

One important thing to note is that if you notice your softgels or gummies clumping together, they’re still OK to take. This doesn’t impact the potency. Simply store them in a cooler environment and they should separate.


For the most part, coconut oil, MCT oil, flax oil, and the like can be kept at room temperature. Coconut oil may change from a solid to a liquid and back again due to temperature – this is normal, so don’t stress out.

Omega-3s and fish oil

Many liquid omega-3 products require refrigeration, and some softgel formulas can too. As always, the directions will tell you what’s best for the product, so if you’re not sure, check the label and get back to enjoying your supplement routine.


Sign up for 15% off your next order.